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Molecules
Volume 11
Issue 4
10.3390/11040212
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Open AccessArticle

2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold

by
David Díaz Díaz
2,
Antonella Converso
1,
K. Barry Sharpless
1 and
M. G. Finn
1,*
1
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, California 92037, USA
2
Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Molecules 2006, 11(4), 212-218; https://0-doi-org.brum.beds.ac.uk/10.3390/11040212
Received: 16 March 2006 / Accepted: 27 March 2006 / Published: 27 March 2006
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Abstract

2,6-Dichloro-9-thiabicyclo[3.3.1]nonane, easily available by an improved condensation of sulfur dichloride, sulfuryl chloride, and 1,5-cyclooctadiene, is a well- behaved scaffold for the nucleophilic substitution of azides and cyanides via neighboring- group participation by the sulfur atom. The products are isolated in high yields with purity >95% by simple extraction and washing protocols. View Full-Text
Keywords: Sulfur mustard; azides; cyanides; neighboring-group participation; multigram synthesis. Sulfur mustard; azides; cyanides; neighboring-group participation; multigram synthesis.
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MDPI and ACS Style

Díaz, D.D.; Converso, A.; Sharpless, K.B.; Finn, M.G. 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold. Molecules 2006, 11, 212-218. https://0-doi-org.brum.beds.ac.uk/10.3390/11040212

AMA Style

Díaz DD, Converso A, Sharpless KB, Finn MG. 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold. Molecules. 2006; 11(4):212-218. https://0-doi-org.brum.beds.ac.uk/10.3390/11040212

Chicago/Turabian Style

Díaz, David D.; Converso, Antonella; Sharpless, K. B.; Finn, M. G. 2006. "2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: Multigram Display of Azide and Cyanide Components on a Versatile Scaffold" Molecules 11, no. 4: 212-218. https://0-doi-org.brum.beds.ac.uk/10.3390/11040212

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