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Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

Prodrugs for Amines

Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal
IBET, Apartado 12, 2781-901 Oeiras, Portugal
School of Pharmacy, Trinity College, Dublin 2, Ireland
Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
(This article belongs to the Special Issue Prodrugs)
The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs. A compilation of the most important approaches ispresented in the form of a table, where the main advantages and disadvantages of eachstrategy are also referred. View Full-Text
Keywords: Prodrugs; amines; enzymatic activation; chemical activation Prodrugs; amines; enzymatic activation; chemical activation
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MDPI and ACS Style

Simplício, A.L.; Clancy, J.M.; Gilmer, J.F. Prodrugs for Amines. Molecules 2008, 13, 519-547.

AMA Style

Simplício AL, Clancy JM, Gilmer JF. Prodrugs for Amines. Molecules. 2008; 13(3):519-547.

Chicago/Turabian Style

Simplício, Ana L., John M. Clancy, and John F. Gilmer 2008. "Prodrugs for Amines" Molecules 13, no. 3: 519-547.

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