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Article

A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats

1
Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
2
Department of Chemistry and Biochemistry, Faculty of Science, Tabuk University, Tabuk P.O. Box 699, Tabuk 71491, Saudi Arabia
3
Faculty of Specific Education, Zagazig University, Zagazig 44519, Egypt
4
Department of Basic and Clinical Medical Science, Faculty of Dentistry, P. Qaseem University, Qaseem 51411, Saudi Arabia
5
Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt
*
Author to whom correspondence should be addressed.
Received: 2 July 2014 / Revised: 30 July 2014 / Accepted: 26 August 2014 / Published: 26 September 2014
(This article belongs to the Section Medicinal Chemistry)
A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group. View Full-Text
Keywords: Lepidium sativum; isoflavonoid; hepatotoxicity Lepidium sativum; isoflavonoid; hepatotoxicity
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MDPI and ACS Style

Sakran, M.; Selim, Y.; Zidan, N. A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats. Molecules 2014, 19, 15440-15451. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules191015440

AMA Style

Sakran M, Selim Y, Zidan N. A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats. Molecules. 2014; 19(10):15440-15451. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules191015440

Chicago/Turabian Style

Sakran, Mohamed, Yasser Selim, and Nahla Zidan. 2014. "A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats" Molecules 19, no. 10: 15440-15451. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules191015440

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