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Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

1
National Institute of Biological Resources, Environmental Research Complex, Incheon 404-708, Korea
2
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Received: 28 August 2015 / Revised: 22 October 2015 / Accepted: 23 October 2015 / Published: 2 November 2015
(This article belongs to the Section Natural Products Chemistry)
Chemotaxonomic metabolite profiling of 62 indigenous Korean plant species was performed by ultrahigh performance liquid chromatography (UHPLC)-linear trap quadrupole-ion trap (LTQ-IT) mass spectrometry/mass spectrometry (MS/MS) combined with multivariate statistical analysis. In partial least squares discriminant analysis (PLS-DA), the 62 species clustered depending on their phylogenetic family, in particular, Aceraceae, Betulaceae, and Fagaceae were distinguished from Rosaceae, Fabaceae, and Asteraceae. Quinic acid, gallic acid, quercetin, quercetin derivatives, kaempferol, and kaempferol derivatives were identified as family-specific metabolites, and were found in relatively high concentrations in Aceraceae, Betulaceae, and Fagaceae. Fagaceae and Asteraceae were selected based on results of PLS-DA and bioactivities to determine the correlation between metabolic differences among plant families and bioactivities. Quinic acid, quercetin, kaempferol, quercetin derivatives, and kaempferol derivatives were found in higher concentrations in Fagaceae than in Asteraceae, and were positively correlated with antioxidant and tyrosinase inhibition activities. These results suggest that metabolite profiling was a useful tool for finding the different metabolic states of each plant family and understanding the correlation between metabolites and bioactivities in accordance with plant family. View Full-Text
Keywords: chemotaxonomy; indigenous plant; metabolite profiling; UHPLC-LTQ-IT-MS/MS; antioxidant activity; tyrosinase inhibition activity chemotaxonomy; indigenous plant; metabolite profiling; UHPLC-LTQ-IT-MS/MS; antioxidant activity; tyrosinase inhibition activity
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MDPI and ACS Style

Lee, S.; Oh, D.-G.; Lee, S.; Kim, G.R.; Lee, J.S.; Son, Y.K.; Bae, C.-H.; Yeo, J.; Lee, C.H. Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities. Molecules 2015, 20, 19719-19734. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules201119652

AMA Style

Lee S, Oh D-G, Lee S, Kim GR, Lee JS, Son YK, Bae C-H, Yeo J, Lee CH. Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities. Molecules. 2015; 20(11):19719-19734. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules201119652

Chicago/Turabian Style

Lee, Sarah, Dong-Gu Oh, Sunmin Lee, Ga R. Kim, Jong S. Lee, Youn K. Son, Chang-Hwan Bae, Joohong Yeo, and Choong H. Lee 2015. "Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities" Molecules 20, no. 11: 19719-19734. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules201119652

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