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Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave

Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA
Author to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 13 February 2015 / Revised: 9 March 2015 / Accepted: 18 March 2015 / Published: 24 March 2015
(This article belongs to the Special Issue Organic Synthesis on Solid Phase)
The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields. View Full-Text
Keywords: microwave irradiation; solid-support; Glaser-Hay microwave irradiation; solid-support; Glaser-Hay
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MDPI and ACS Style

Lampkowski, J.S.; Maza, J.C.; Verma, S.; Young, D.D. Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave. Molecules 2015, 20, 5276-5285.

AMA Style

Lampkowski JS, Maza JC, Verma S, Young DD. Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave. Molecules. 2015; 20(4):5276-5285.

Chicago/Turabian Style

Lampkowski, Jessica S., Johnathan C. Maza, Sanjana Verma, and Douglas D. Young 2015. "Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave" Molecules 20, no. 4: 5276-5285.

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