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Article

A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

1
Department of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, Italy
2
Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 8 May 2015 / Revised: 22 June 2015 / Accepted: 24 June 2015 / Published: 26 June 2015
(This article belongs to the Section Medicinal Chemistry)
Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM. View Full-Text
Keywords: antifungal activity; dermatophytes; M. gypseum; α-bisabolol; TEM; skin lightener antifungal activity; dermatophytes; M. gypseum; α-bisabolol; TEM; skin lightener
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MDPI and ACS Style

Romagnoli, C.; Baldisserotto, A.; Malisardi, G.; Vicentini, C.B.; Mares, D.; Andreotti, E.; Vertuani, S.; Manfredini, S. A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum. Molecules 2015, 20, 11765-11776. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules200711765

AMA Style

Romagnoli C, Baldisserotto A, Malisardi G, Vicentini CB, Mares D, Andreotti E, Vertuani S, Manfredini S. A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum. Molecules. 2015; 20(7):11765-11776. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules200711765

Chicago/Turabian Style

Romagnoli, Carlo, Anna Baldisserotto, Gemma Malisardi, Chiara B. Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, and Stefano Manfredini. 2015. "A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum" Molecules 20, no. 7: 11765-11776. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules200711765

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