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Article

Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum

1
Department of Life Sciences, University of Modena and Reggio Emilia, Viale Caduti in Guerra 127, 41121 Modena, Italy
2
Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 14 July 2016 / Revised: 25 September 2016 / Accepted: 27 September 2016 / Published: 30 September 2016
(This article belongs to the Section Medicinal Chemistry)
In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Arthroderma cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Nannizzia gypsea, Trichophyton rubrum and Trichophyton tonsurans. Among the three tested resorcinols, only two showed promising properties, with the ability to inhibit the growth of all tested dermatophytes; additionally, the IC50 values of these two resorcinols against the nine dermatophytes confirmed their good antifungal activity, particularly for phenylethyl resorcinol against M. gypseum. Ultrastructural alterations exhibited by the fungus were observed using scanning electron microscopy and transmission electron microscopy and reflected a dose-dependent response to treatment with the activation of defence and self-preservation strategies. View Full-Text
Keywords: resorcinol derivatives; dermatophytes; Microsporum gypseum; antifungal activity; TEM; SEM resorcinol derivatives; dermatophytes; Microsporum gypseum; antifungal activity; TEM; SEM
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MDPI and ACS Style

Romagnoli, C.; Baldisserotto, A.; Vicentini, C.B.; Mares, D.; Andreotti, E.; Vertuani, S.; Manfredini, S. Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum. Molecules 2016, 21, 1306. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21101306

AMA Style

Romagnoli C, Baldisserotto A, Vicentini CB, Mares D, Andreotti E, Vertuani S, Manfredini S. Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum. Molecules. 2016; 21(10):1306. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21101306

Chicago/Turabian Style

Romagnoli, Carlo, Anna Baldisserotto, Chiara B. Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, and Stefano Manfredini. 2016. "Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum" Molecules 21, no. 10: 1306. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21101306

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