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Article

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

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Dipartimento di Scienze della Vita e dell’Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy
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Dipartimento di Scienze della Vita e Biotecnologie, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy
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Dipartmento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, Via Fossato di Mortara 17-19, Ferrara I-44121, Italy
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KU Leuven—University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium
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Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 31 March 2016 / Revised: 22 April 2016 / Accepted: 25 April 2016 / Published: 30 April 2016
(This article belongs to the Section Medicinal Chemistry)
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range. View Full-Text
Keywords: benzimidazoles; hydrazones; antiproliferative activity benzimidazoles; hydrazones; antiproliferative activity
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MDPI and ACS Style

Onnis, V.; Demurtas, M.; Deplano, A.; Balboni, G.; Baldisserotto, A.; Manfredini, S.; Pacifico, S.; Liekens, S.; Balzarini, J. Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones. Molecules 2016, 21, 579. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050579

AMA Style

Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J. Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones. Molecules. 2016; 21(5):579. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050579

Chicago/Turabian Style

Onnis, Valentina, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, and Jan Balzarini. 2016. "Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones" Molecules 21, no. 5: 579. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules21050579

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