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Article

Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines

Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, China
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Authors to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 16 January 2017 / Revised: 14 February 2017 / Accepted: 16 February 2017 / Published: 22 February 2017
(This article belongs to the Collection Heterocyclic Compounds)
A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.). The asymmetric version of this method was realized by using an easily available chiral sulfur ylide, affording products with moderate to good stereoselectivity. View Full-Text
Keywords: spirocyclopropanes; diastereoselective synthesis; catalyst free; sulfur ylide spirocyclopropanes; diastereoselective synthesis; catalyst free; sulfur ylide
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MDPI and ACS Style

Li, Y.; Li, Q.-Z.; Huang, L.; Liang, H.; Yang, K.-C.; Leng, H.-J.; Liu, Y.; Shen, X.-D.; Gou, X.-J.; Li, J.-L. Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines. Molecules 2017, 22, 328. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22020328

AMA Style

Li Y, Li Q-Z, Huang L, Liang H, Yang K-C, Leng H-J, Liu Y, Shen X-D, Gou X-J, Li J-L. Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines. Molecules. 2017; 22(2):328. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22020328

Chicago/Turabian Style

Li, Yi, Qing-Zhu Li, Li Huang, Hong Liang, Kai-Chuan Yang, Hai-Jun Leng, Yue Liu, Xu-Dong Shen, Xiao-Jun Gou, and Jun-Long Li. 2017. "Diastereoselective Synthesis of Spirocyclopropanes under Mild Conditions via Formal [2 + 1] Cycloadditions Using 2,3-Dioxo-4-benzylidene-pyrrolidines" Molecules 22, no. 2: 328. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22020328

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