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Article

A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

1
Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France
2
Institute of Molecular Chemistry and Materials of Orsay, UMR CNRS 8182, University of Paris-Sud, Building 420, 91400 Orsay, France
*
Author to whom correspondence should be addressed.
Academic Editor: Thierry Besson
Received: 27 February 2018 / Revised: 12 March 2018 / Accepted: 16 March 2018 / Published: 18 March 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes. View Full-Text
Keywords: PEG-400; nucleophilic aromatic substitution; nitrogen fused heterocycles PEG-400; nucleophilic aromatic substitution; nitrogen fused heterocycles
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MDPI and ACS Style

Campos, J.F.; Loubidi, M.; Scherrmann, M.-C.; Berteina-Raboin, S. A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles. Molecules 2018, 23, 684. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23030684

AMA Style

Campos JF, Loubidi M, Scherrmann M-C, Berteina-Raboin S. A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles. Molecules. 2018; 23(3):684. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23030684

Chicago/Turabian Style

Campos, Joana F., Mohammed Loubidi, Marie-Christine Scherrmann, and Sabine Berteina-Raboin. 2018. "A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles" Molecules 23, no. 3: 684. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23030684

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