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Article

Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum

1
Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Apartado 0843-01103, Panama
2
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
3
Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Panama, Apartado 0843-01103, Panama
4
Smithsonian Tropical Research Institute, Balboa, Ancon P.O. Box 0843-03092, Panama
5
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
6
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 30 July 2018 / Revised: 24 August 2018 / Accepted: 25 August 2018 / Published: 29 August 2018
(This article belongs to the Section Natural Products Chemistry)
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+. View Full-Text
Keywords: Bacillus; surfactins; pumilacidins; coral-associated bacteria; P. falciparum; apoptosis Bacillus; surfactins; pumilacidins; coral-associated bacteria; P. falciparum; apoptosis
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MDPI and ACS Style

Torres-Mendoza, D.; Coronado, L.M.; Pineda, L.M.; Guzmán, H.M.; Dorrestein, P.C.; Spadafora, C.; Gutiérrez, M. Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum. Molecules 2018, 23, 2179. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23092179

AMA Style

Torres-Mendoza D, Coronado LM, Pineda LM, Guzmán HM, Dorrestein PC, Spadafora C, Gutiérrez M. Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum. Molecules. 2018; 23(9):2179. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23092179

Chicago/Turabian Style

Torres-Mendoza, Daniel, Lorena M. Coronado, Laura M. Pineda, Héctor M. Guzmán, Pieter C. Dorrestein, Carmenza Spadafora, and Marcelino Gutiérrez. 2018. "Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum" Molecules 23, no. 9: 2179. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules23092179

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