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Article

Coralmycin Derivatives with Potent Anti-Gram Negative Activity Produced by the Myxobacteria Corallococcus coralloides M23

by 1,2,†, 1,3,†, 1,2 and 1,2,*
1
Superbacteria Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Korea
2
Department of Bio-Molecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Yusong, Daejeon 305-806, Korea
3
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
*
Author to whom correspondence should be addressed.
They contributed equally to this work.
Received: 20 March 2019 / Revised: 6 April 2019 / Accepted: 8 April 2019 / Published: 9 April 2019
(This article belongs to the Section Natural Products Chemistry)
Seven new coralmycin derivatives, coralmycins C (1), D (2), E (3), F (4), G (5), H (6), and I (7), along with three known compounds, cystobactamids 891-2 (8), 905-2 (9), and 507 (10), were isolated from a large-scale culture of the myxobacteria Corallococcus coralloides M23. The structures of these compounds, including their relative stereochemistries, were elucidated by interpretation of their spectroscopic and CD data. The structure-activity relationships of their antibacterial and DNA gyrase inhibitory activities indicated that the para-nitrobenzoic acid unit is critical for the inhibition of DNA gyrase and bacterial growth, while the nitro moiety of the para-nitrobenzoic acid unit and the isopropyl chain at C-4 could be important for permeability into certain Gram-negative bacteria, including Pseudomonas aeruginosa and Klebsiella pneumoniae, and the β-methoxyasparagine moiety could affect cellular uptake into all tested bacteria. These results could facilitate the chemical optimization of coralmycins for the treatment of multidrug-resistant Gram-negative bacteria. View Full-Text
Keywords: Corallococcus coralloides; coralmycin; antibacterial; Gram-negative; DNA gyrase Corallococcus coralloides; coralmycin; antibacterial; Gram-negative; DNA gyrase
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MDPI and ACS Style

Kim, B.-M.; Minh, N.V.; Choi, H.-Y.; Kim, W.-G. Coralmycin Derivatives with Potent Anti-Gram Negative Activity Produced by the Myxobacteria Corallococcus coralloides M23. Molecules 2019, 24, 1390. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24071390

AMA Style

Kim B-M, Minh NV, Choi H-Y, Kim W-G. Coralmycin Derivatives with Potent Anti-Gram Negative Activity Produced by the Myxobacteria Corallococcus coralloides M23. Molecules. 2019; 24(7):1390. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24071390

Chicago/Turabian Style

Kim, Bo-Min, Nguyen V. Minh, Ha-Young Choi, and Won-Gon Kim. 2019. "Coralmycin Derivatives with Potent Anti-Gram Negative Activity Produced by the Myxobacteria Corallococcus coralloides M23" Molecules 24, no. 7: 1390. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24071390

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