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Review

Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care

1
Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan
2
Department of Plastic Surgery, Show Chwan Memorial Hospital, Changhua 500, Taiwan
3
Department of Life Sciences, National Chung Hsing University, Taichung City 402, Taiwan
4
Cardiovascular Clinic, Kaohsiung Armed Forces General Hospital, Kaohsiung City 802, Taiwan
5
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
6
Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Ana Paula Duarte, Ângelo Luís and Eugenia Gallardo
Received: 18 September 2020 / Revised: 23 October 2020 / Accepted: 24 October 2020 / Published: 30 October 2020
(This article belongs to the Special Issue Natural Products: Therapeutic Properties and Beyond)
Natural products are favored because of their non-toxicity, low irritants, and market reacceptance. We collected examples, according to ancient wisdom, of natural products to be applied in transdermal delivery. A transdermal delivery system, including different types of agents, such as ointments, patches, and gels, has long been used for skin concerns. In recent years, many novel transdermal applications, such as nanoemulsions, liposomes, lipid nanoparticles, and microneedles, have been reported. Nanosized drug delivery systems are widely applied in natural product deliveries. Nanosized materials notably enhance bioavailability and solubility, and are reported to improve the transdermal permeation of many substances compared with conventional topical formulations. Natural products have been made into nanosized biomaterials in order to enhance the penetration effect. Before introducing the novel transdermal applications of natural products, we present traditional methods within this article. The descriptions of novel transdermal applications are classified into three parts: liposomes, emulsions, and lipid nanoparticles. Each section describes cases that are related to promising natural product transdermal use. Finally, we summarize the outcomes of various studies on novel transdermal agents applied to skin treatments. View Full-Text
Keywords: natural products; skin; transdermal delivery; liposome; emulsion; lipid nanoparticle natural products; skin; transdermal delivery; liposome; emulsion; lipid nanoparticle
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MDPI and ACS Style

Cheng, Y.-C.; Li, T.S.; Su, H.L.; Lee, P.C.; Wang, H.-M.D. Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care. Molecules 2020, 25, 5051. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25215051

AMA Style

Cheng Y-C, Li TS, Su HL, Lee PC, Wang H-MD. Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care. Molecules. 2020; 25(21):5051. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25215051

Chicago/Turabian Style

Cheng, Ying-Chen, Tzong S. Li, Hong L. Su, Po C. Lee, and Hui-Min D. Wang. 2020. "Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care" Molecules 25, no. 21: 5051. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25215051

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