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Article

Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application

1
Interuniversity National Consortiums of Materials Science and Technology (INSTM), 50121 Firenze, Italy
2
Department of Civil and Industrial Engineering, University of Pisa, 56126 Pisa, Italy
3
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
4
Linari Engineering s.r.l., 56121 Pisa, Italy
5
Biomass Valorization Platform-Materials, Celabor s.c.r.l., 4650 Chaineux, Belgium
*
Authors to whom correspondence should be addressed.
Academic Editor: Stefania Cometa
Received: 1 July 2021 / Accepted: 15 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue New Trends in Skin Care: Topical Delivery of Cosmeceutical Molecules)
Cosmetics has recently focused on biobased skin-compatible materials. Materials from natural sources can be used to produce more sustainable skin contact products with enhanced bioactivity. Surface functionalization using natural-based nano/microparticles is thus a subject of study, aimed at better understanding the skin compatibility of many biopolymers also deriving from biowaste. This research investigated electrospray as a method for surface modification of cellulose tissues with chitin nanofibrils (CNs) using two different sources—namely, vegetable (i.e., from fungi), and animal (from crustaceans)—and different solvent systems to obtain a biobased and skin-compatible product. The surface of cellulose tissues was uniformly decorated with electrosprayed CNs. Biological analysis revealed that all treated samples were suitable for skin applications since human dermal keratinocytes (i.e., HaCaT cells) successfully adhered to the processed tissues and were viable after being in contact with released substances in culture media. These results indicate that the use of solvents did not affect the final cytocompatibility due to their effective evaporation during the electrospray process. Such treatments did not also affect the characteristics of cellulose; in addition, they showed promising anti-inflammatory and indirect antimicrobial activity toward dermal keratinocytes in vitro. Specifically, cellulosic substrates decorated with nanochitins from shrimp showed strong immunomodulatory activity by first upregulating then downregulating the pro-inflammatory cytokines, whereas nanochitins from mushrooms displayed an overall anti-inflammatory activity via a slight decrement of the pro-inflammatory cytokines and increment of the anti-inflammatory marker. Electrospray could represent a green method for surface modification of sustainable and biofunctional skincare products. View Full-Text
Keywords: surface functionalization; chitin nanofibril; cellulose; skincare; anti-inflammatory; biobased surface functionalization; chitin nanofibril; cellulose; skincare; anti-inflammatory; biobased
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MDPI and ACS Style

Azimi, B.; Ricci, C.; Fusco, A.; Zavagna, L.; Linari, S.; Donnarumma, G.; Hadrich, A.; Cinelli, P.; Coltelli, M.-B.; Danti, S.; Lazzeri, A. Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application. Molecules 2021, 26, 4374. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26144374

AMA Style

Azimi B, Ricci C, Fusco A, Zavagna L, Linari S, Donnarumma G, Hadrich A, Cinelli P, Coltelli M-B, Danti S, Lazzeri A. Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application. Molecules. 2021; 26(14):4374. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26144374

Chicago/Turabian Style

Azimi, Bahareh, Claudio Ricci, Alessandra Fusco, Lorenzo Zavagna, Stefano Linari, Giovanna Donnarumma, Ahdi Hadrich, Patrizia Cinelli, Maria-Beatrice Coltelli, Serena Danti, and Andrea Lazzeri. 2021. "Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application" Molecules 26, no. 14: 4374. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26144374

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