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Article

Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry

1
Department of Chemistry, SRM University, Delhi-NCR, Haryana, 39, RGEC, Sonepat 131 029, India
2
Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India
3
Department of Sciences, University of Rome “Roma Tre”, 00146 Rome, Italy
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Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca, Scientifica 1, 00133 Rome, Italy
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Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India
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Department of Chemistry and Environmental Science, Medgar Evers College, The City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, USA
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Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University, P. le. Aldo Moro 5, 00185 Rome, Italy
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Institute of Chemistry for Life and Health Sciences, Chimie ParisTech, PSL Research University, CNRS, UMR8060, 11 rue Pierre et Marie Curie, F-75005 Paris, France
*
Author to whom correspondence should be addressed.
In loving and fond memory of our long-term Colleague, Collaborator and Friend, (Late) Professor Dr. H. G. Raj.
Academic Editor: Vincenzo Barone
Received: 21 June 2021 / Revised: 25 July 2021 / Accepted: 4 August 2021 / Published: 8 August 2021
(This article belongs to the Special Issue Reactivity and Properties of Radicals and Radical Ions)
The purpose of this study was to examine the free radical scavenging and antioxidant activities of ellagic acid (EA) and ellagic acid peracetate (EAPA) by measuring their reactions with the radicals, 2,2-diphenyl-1-picrylhydrazyl and galvinoxyl using EPR spectroscopy. We have also evaluated the influence of EA and EAPA on the ROS production in L-6 myoblasts and rat liver microsomal lipid peroxidation catalyzed by NADPH. The results obtained clearly indicated that EA has tremendous ability to scavenge free radicals, even at concentration of 1 µM. Interestingly even in the absence of esterase, EAPA, the acetylated product of EA, was also found to be a good scavenger but at a relatively slower rate. Kinetic studies revealed that both EA and EAPA have ability to scavenge free radicals at the concentrations of 1 µM over extended periods of time. In cellular systems, EA and EAPA were found to have similar potentials for the inhibition of ROS production in L-6 myoblasts and NADPH-dependent catalyzed microsomal lipid peroxidation. View Full-Text
Keywords: free radical; ellagic acid; ellagic acid peracetate; electron paramagnetic resonance; cytotoxicity; L-6 myoblasts free radical; ellagic acid; ellagic acid peracetate; electron paramagnetic resonance; cytotoxicity; L-6 myoblasts
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MDPI and ACS Style

Kumar, A.; Kaushik, P.; Incerpi, S.; Pedersen, J.Z.; Goel, S.; Prasad, A.K.; Rohil, V.; Parmar, V.S.; Saso, L.; Len, C. Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry. Molecules 2021, 26, 4800. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26164800

AMA Style

Kumar A, Kaushik P, Incerpi S, Pedersen JZ, Goel S, Prasad AK, Rohil V, Parmar VS, Saso L, Len C. Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry. Molecules. 2021; 26(16):4800. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26164800

Chicago/Turabian Style

Kumar, Ajit, Preeti Kaushik, Sandra Incerpi, Jens Z. Pedersen, Sanjay Goel, Ashok K. Prasad, Vishwajeet Rohil, Virinder S. Parmar, Luciano Saso, and Christophe Len. 2021. "Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry" Molecules 26, no. 16: 4800. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26164800

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