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Article

Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases

1
Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, Italy
2
Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, 98122 Messina, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Masahide Hamaguchi and Ana Paula Duarte
Received: 29 January 2021 / Revised: 18 March 2021 / Accepted: 19 March 2021 / Published: 22 March 2021
(This article belongs to the Special Issue Natural Products: Therapeutic Properties and Beyond)
Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9. View Full-Text
Keywords: periodontitis; cardiovascular disease; matrix metalloproteinases; serum; saliva; clinical trial periodontitis; cardiovascular disease; matrix metalloproteinases; serum; saliva; clinical trial
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MDPI and ACS Style

Isola, G.; Polizzi, A.; Ronsivalle, V.; Alibrandi, A.; Palazzo, G.; Lo Giudice, A. Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases. Molecules 2021, 26, 1777. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26061777

AMA Style

Isola G, Polizzi A, Ronsivalle V, Alibrandi A, Palazzo G, Lo Giudice A. Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases. Molecules. 2021; 26(6):1777. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26061777

Chicago/Turabian Style

Isola, Gaetano, Alessandro Polizzi, Vincenzo Ronsivalle, Angela Alibrandi, Giuseppe Palazzo, and Antonino Lo Giudice. 2021. "Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases" Molecules 26, no. 6: 1777. https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26061777

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