Next Article in Journal
Zeranol Down-Regulates p53 Expression in Primary Cultured Human Breast Cancer Epithelial Cells through Epigenetic Modification
Previous Article in Journal
Use of a Reflectance Spectroscopy Accessory for Optical Characterization of ZnO-Bi2O3-TiO2 Ceramics
Previous Article in Special Issue
Cell Surface Markers in Colorectal Cancer Prognosis
Article

IL8 and Cathepsin B as Melanoma Serum Biomarkers

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Division of Hematology-Oncology, HUP, 16 Penn Tower, Philadelphia, PA 19104, USA
3
The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(3), 1505-1518; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms12031505
Received: 3 December 2010 / Revised: 15 February 2011 / Accepted: 22 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Biomarkers)
Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (p < 0.05). More importantly, the combination of IL-8 and cathepsin B were also studied as a prognosis marker for melanoma mortality. Our study provides a novel approach to examine serum biomarkers. View Full-Text
Keywords: IL-8; cathepsin B; melanoma; serum interference IL-8; cathepsin B; melanoma; serum interference
Show Figures

Graphical abstract

MDPI and ACS Style

Zhang, H.; Fu, T.; McGettigan, S.; Kumar, S.; Liu, S.; Speicher, D.; Schuchter, L.; Xu, X. IL8 and Cathepsin B as Melanoma Serum Biomarkers. Int. J. Mol. Sci. 2011, 12, 1505-1518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms12031505

AMA Style

Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, Xu X. IL8 and Cathepsin B as Melanoma Serum Biomarkers. International Journal of Molecular Sciences. 2011; 12(3):1505-1518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms12031505

Chicago/Turabian Style

Zhang, Hongtao, Ting Fu, Suzanne McGettigan, Suresh Kumar, Shujing Liu, David Speicher, Lynn Schuchter, and Xiaowei Xu. 2011. "IL8 and Cathepsin B as Melanoma Serum Biomarkers" International Journal of Molecular Sciences 12, no. 3: 1505-1518. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms12031505

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop