Next Article in Journal
A Simple Bioconjugate Attachment Protocol for Use in Single Molecule Force Spectroscopy Experiments Based on Mixed Self-Assembled Monolayers
Previous Article in Journal
Injury-Induced Accumulation of Glial Cell Line-Derived Neurotrophic Factor in the Rostral Part of the Injured Rat Spinal Cord
Article

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease

by 1,2,†, 1,2,†, 1,2, 1,2, 1,2, 1,2, 1,2,* and 3
1
Center of Bioinformatics, Northwest A & F University, Yangling 712100, Shaanxi, China
2
College of Life Sciences, Northwest A & F University, Yangling 712100, Shaanxi, China
3
Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy Sciences, Dalian, Liaoning 116023, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(10), 13501-13520; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms131013501
Received: 5 September 2012 / Revised: 11 October 2012 / Accepted: 15 October 2012 / Published: 19 October 2012
Traditional Chinese Medicine (TCM) involves a broad range of empirical testing and refinement and plays an important role in the health maintenance for people all over the world. However, due to the complexity of Chinese herbs, a full understanding of TCM’s action mechanisms is still unavailable despite plenty of successful applications of TCM in the treatment of various diseases, including especially cardiovascular diseases (CVD), one of the leading causes of death. Thus in the present work, by incorporating the chemical predictors, target predictors and network construction approaches, an integrated system of TCM has been constructed to systematically uncover the underlying action mechanisms of TCM. From three representative Chinese herbs, i.e., Ligusticum chuanxiong Hort., Dalbergia odorifera T. Chen and Corydalis yanhusuo WT Wang which have been widely used in CVD treatment, by combinational use of drug absorption, distribution, metabolism and excretion (ADME) screening and network pharmacology techniques, we have generated 64 bioactive ingredients and identified 54 protein targets closely associated with CVD, of which 29 are common targets (52.7%) of the three herbs. The result provides new information on the efficiency of the Chinese herbs for the treatment of CVD and also explains one of the basic theories of TCM, i.e., “multiple herbal drugs can treat one disease”. The predicted potential targets were then mapped to target-disease and target-signal pathway connections, which revealed the relationships of the active ingredients with their potential targets, diseases and signal systems. This means that for the first time, the action mechanism of these three important Chinese herbs for the treatment of CVD is uncovered, by generating and identifying both their active ingredients and novel targets specifically related to CVD, which clarifies some of the common conceptions in TCM, and thus provides clues to modernize such specific herbal medicines. View Full-Text
Keywords: systems pharmacology; ADME; Traditional Chinese Medicine; cardiovascular diseases systems pharmacology; ADME; Traditional Chinese Medicine; cardiovascular diseases
Show Figures

Graphical abstract

MDPI and ACS Style

Li, B.; Xu, X.; Wang, X.; Yu, H.; Li, X.; Tao, W.; Wang, Y.; Yang, L. A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease. Int. J. Mol. Sci. 2012, 13, 13501-13520. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms131013501

AMA Style

Li B, Xu X, Wang X, Yu H, Li X, Tao W, Wang Y, Yang L. A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease. International Journal of Molecular Sciences. 2012; 13(10):13501-13520. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms131013501

Chicago/Turabian Style

Li, Bohui, Xue Xu, Xia Wang, Hua Yu, Xiuxiu Li, Weiyang Tao, Yonghua Wang, and Ling Yang. 2012. "A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease" International Journal of Molecular Sciences 13, no. 10: 13501-13520. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms131013501

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop