Next Article in Journal
Tyrosol and Its Analogues Inhibit Alpha-Melanocyte-Stimulating Hormone Induced Melanogenesis
Next Article in Special Issue
High-Resolution Imaging Reveals New Features of Nuclear Export of mRNA through the Nuclear Pore Complexes
Previous Article in Journal
Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application
Previous Article in Special Issue
New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
Review

Role of Sam68 in Post-Transcriptional Gene Regulation

Department of Medical Biochemistry and Molecular Biology and Immunology, UGC Clinical Biochemistry, Virgen Macarena University Hospital, Avenue. Sánchez Pizjuan 4, Medical School, University of Seville, Seville 41009, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(12), 23402-23419; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141223402
Received: 13 September 2013 / Revised: 11 November 2013 / Accepted: 13 November 2013 / Published: 28 November 2013
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also contains some domains predicted to bind critical components in signal transduction pathways. In response to phosphorylation and other post-transcriptional modifications, Sam68 has been shown to have the ability to link signal transduction pathways to downstream effects regulating RNA metabolism, including transcription, alternative splicing or RNA transport. In addition to its function as a docking protein in some signaling pathways, this prototypic STAR protein has been identified to have a nuclear localization and to take part in the formation of both nuclear and cytosolic multi-molecular complexes such as Sam68 nuclear bodies and stress granules. Coupling with other proteins and RNA targets, Sam68 may play a role in the regulation of differential expression and mRNA processing and translation according to internal and external signals, thus mediating important physiological functions, such as cell death, proliferation or cell differentiation. View Full-Text
Keywords: Sam68; RNA-binding protein; post-transcriptional regulation Sam68; RNA-binding protein; post-transcriptional regulation
MDPI and ACS Style

Sánchez-Jiménez, F.; Sánchez-Margalet, V. Role of Sam68 in Post-Transcriptional Gene Regulation. Int. J. Mol. Sci. 2013, 14, 23402-23419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141223402

AMA Style

Sánchez-Jiménez F, Sánchez-Margalet V. Role of Sam68 in Post-Transcriptional Gene Regulation. International Journal of Molecular Sciences. 2013; 14(12):23402-23419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141223402

Chicago/Turabian Style

Sánchez-Jiménez, Flora, and Víctor Sánchez-Margalet. 2013. "Role of Sam68 in Post-Transcriptional Gene Regulation" International Journal of Molecular Sciences 14, no. 12: 23402-23419. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141223402

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop