Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease
There is growing evidence that increased levels of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) may contribute to endothelial dysfunction. Studies in animal models as well as in humans have suggested that the increase in ADMA occurs at a time when vascular disease has not yet become clinically evident. ADMA competitively inhibits NO elaboration by displacing L-arginine from NO synthase. In a concentration-dependent manner, it thereby interferes not only with endothelium-dependent, NO-mediated vasodilation, but also with other biological functions exerted by NO. The upshot may be a pro-atherogenic state. Recently, several studies have investigated the effect of various therapeutical interventions on ADMA plasma concentrations. [...] View Full-Text
Franceschelli, S.; Ferrone, A.; Pesce, M.; Riccioni, G.; Speranza, L. Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease. Int. J. Mol. Sci. 2013, 14, 24412-24421. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141224412
Franceschelli S, Ferrone A, Pesce M, Riccioni G, Speranza L. Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease. International Journal of Molecular Sciences. 2013; 14(12):24412-24421. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141224412
Chicago/Turabian StyleFranceschelli, Sara; Ferrone, Alessio; Pesce, Mirko; Riccioni, Graziano; Speranza, Lorenza. 2013. "Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease" Int. J. Mol. Sci. 14, no. 12: 24412-24421. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms141224412