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Review

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

1
Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy
2
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Kirchberg Hospital, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg
3
College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(2), 2388-2409; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022388
Received: 5 December 2012 / Revised: 14 January 2013 / Accepted: 21 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in this pathology. This review focuses on recently described networks most likely involved in an integrated manner in the course of PD. View Full-Text
Keywords: neurodegenerative diseases; Parkinson’s disease (PD); base excision repair (BER); mitochondria; oxidative stress; reactive oxidative species (ROS); reactive nitrogen species (RNS); c-Abl; reduced glutathione (GSH); oxidized glutathione (GSS-) neurodegenerative diseases; Parkinson’s disease (PD); base excision repair (BER); mitochondria; oxidative stress; reactive oxidative species (ROS); reactive nitrogen species (RNS); c-Abl; reduced glutathione (GSH); oxidized glutathione (GSS-)
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MDPI and ACS Style

Ciccone, S.; Maiani, E.; Bellusci, G.; Diederich, M.; Gonfloni, S. Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress. Int. J. Mol. Sci. 2013, 14, 2388-2409. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022388

AMA Style

Ciccone S, Maiani E, Bellusci G, Diederich M, Gonfloni S. Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress. International Journal of Molecular Sciences. 2013; 14(2):2388-2409. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022388

Chicago/Turabian Style

Ciccone, Sarah, Emiliano Maiani, Giovanna Bellusci, Marc Diederich, and Stefania Gonfloni. 2013. "Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress" International Journal of Molecular Sciences 14, no. 2: 2388-2409. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms14022388

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