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Article

Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells

1
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
2
Department of Clinical Laboratories, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(7), 15092-15104; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140715092
Received: 15 May 2013 / Revised: 11 July 2013 / Accepted: 15 July 2013 / Published: 19 July 2013
Uveal melanoma (UM) is the most common primary intraocular malignancy and the leading potentially fatal primary intraocular disease in adults. Melanoma antigen recognized by T-cells (MART-1) has been studied extensively as a clinically important diagnostic marker for melanoma, however, its biological function remains unclear. In the present study, the UM cell line SP6.5, which showed a high level of MART-1 expression, was subjected to small interfering RNA-mediated silencing of MART-1. Silencing of MART-1 expression increased the migration ability of SP6.5 cells and down-regulated the expression of the metastasis suppressor NM23. Our results suggest that MART-1 is a candidate target for the development of therapeutic strategies for UM and in particular for the suppression of metastasis associated with this malignancy. View Full-Text
Keywords: uveal melanoma; MART-1; NM23; migration ability uveal melanoma; MART-1; NM23; migration ability
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MDPI and ACS Style

Zhang, Y.; Jia, R.; Wang, J.; Xu, X.; Yao, Y.; Ge, S.; Fan, X. Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells. Int. J. Mol. Sci. 2013, 14, 15092-15104. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140715092

AMA Style

Zhang Y, Jia R, Wang J, Xu X, Yao Y, Ge S, Fan X. Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells. International Journal of Molecular Sciences. 2013; 14(7):15092-15104. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140715092

Chicago/Turabian Style

Zhang, Yidan, Renbing Jia, Jing Wang, Xiaofang Xu, Yuting Yao, Shengfan Ge, and Xianqun Fan. 2013. "Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells" International Journal of Molecular Sciences 14, no. 7: 15092-15104. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140715092

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