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Article

Celf1 Is Required for Formation of Endoderm-Derived Organs in Zebrafish

Gene Regulation Research, Nara Institute Science and Technology, 8916-5 Takayama, Nara 630-0101, Japan
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Int. J. Mol. Sci. 2013, 14(9), 18009-18023; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140918009
Received: 25 June 2013 / Revised: 21 August 2013 / Accepted: 26 August 2013 / Published: 3 September 2013
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
We recently reported that an RNA binding protein called Cugbp Elav-like family member 1 (Celf1) regulates somite symmetry and left-right patterning in zebrafish. In this report, we show additional roles of Celf1 in zebrafish organogenesis. When celf1 is knocked down by using an antisense morpholino oligonucleotides (MO), liver buds fail to form, and pancreas buds do not form a cluster, suggesting earlier defects in endoderm organogenesis. As expected, we found failures in endoderm cell growth and migration during gastrulation in embryos injected with celf1-MOs. RNA immunoprecipitation revealed that Celf1 binds to gata5 and cdc42 mRNAs which are known to be involved in cell growth and migration, respectively. Our results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets. View Full-Text
Keywords: post-transcriptional regulation; endoderm; liver; pancreas; movement; proliferation post-transcriptional regulation; endoderm; liver; pancreas; movement; proliferation
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MDPI and ACS Style

Tahara, N.; Bessho, Y.; Matsui, T. Celf1 Is Required for Formation of Endoderm-Derived Organs in Zebrafish. Int. J. Mol. Sci. 2013, 14, 18009-18023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140918009

AMA Style

Tahara N, Bessho Y, Matsui T. Celf1 Is Required for Formation of Endoderm-Derived Organs in Zebrafish. International Journal of Molecular Sciences. 2013; 14(9):18009-18023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140918009

Chicago/Turabian Style

Tahara, Naoyuki, Yasumasa Bessho, and Takaaki Matsui. 2013. "Celf1 Is Required for Formation of Endoderm-Derived Organs in Zebrafish" International Journal of Molecular Sciences 14, no. 9: 18009-18023. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms140918009

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