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Review

The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation

by 1, 1 and 1,2,*
1
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
2
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(3), 4837-4855; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms15034837
Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 11 March 2014 / Published: 19 March 2014
(This article belongs to the Collection G Protein-Coupled Receptor Signaling and Regulation)
The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. Dependent on the tissues and cells, activation of GHSR may trigger a diversity of signaling mechanisms and subsequent distinct physiological responses. Distinct regulation of GHSR occurs at levels of transcription, receptor interaction and internalization. Here we review the current understanding on the intracellular signaling pathways of GHSR and its modulation. An overview of the molecular structure of GHSR is presented first, followed by the discussion on its signaling mechanisms. Finally, potential mechanisms regulating GHSR are reviewed. View Full-Text
Keywords: ghrelin receptor; constitutive activity; intracellular signaling; [Ca2+]i; AMPK; mTOR; MAPK; PI3K ghrelin receptor; constitutive activity; intracellular signaling; [Ca2+]i; AMPK; mTOR; MAPK; PI3K
MDPI and ACS Style

Yin, Y.; Li, Y.; Zhang, W. The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation. Int. J. Mol. Sci. 2014, 15, 4837-4855. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms15034837

AMA Style

Yin Y, Li Y, Zhang W. The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation. International Journal of Molecular Sciences. 2014; 15(3):4837-4855. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms15034837

Chicago/Turabian Style

Yin, Yue, Yin Li, and Weizhen Zhang. 2014. "The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation" International Journal of Molecular Sciences 15, no. 3: 4837-4855. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms15034837

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