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Identification and Functional Analysis of MicroRNAs in Mice following Focal Cerebral Ischemia Injury
Review

MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury

by 1,†, 2,†, 2,* and 2,*
1
Graduate School, Tianjin University of Traditional Chinese Medicine, 312 An Shan Xi Road, Nan Kai District, Tianjin 300193, China
2
Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2015, 16(10), 24895-24917; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161024895
Received: 16 August 2015 / Revised: 25 September 2015 / Accepted: 8 October 2015 / Published: 20 October 2015
(This article belongs to the Special Issue MicroRNA Regulation)
Cerebral ischemia-reperfusion injury involves multiple independently fatal terminal pathways in the mitochondria. These pathways include the reactive oxygen species (ROS) generation caused by changes in mitochondrial membrane potential and calcium overload, resulting in apoptosis via cytochrome c (Cyt c) release. In addition, numerous microRNAs are associated with the overall process. In this review, we first briefly summarize the mitochondrial changes in cerebral ischemia-reperfusion and then describe the possible molecular mechanism of miRNA-regulated mitochondrial function, which likely includes oxidative stress and energy metabolism, as well as apoptosis. On the basis of the preceding analysis, we conclude that studies of microRNAs that regulate mitochondrial function will expedite the development of treatments for cerebral ischemia-reperfusion injury. View Full-Text
Keywords: ischemic-reperfusion; mitochondria; miRNAs; cerebral ischemic-reperfusion; mitochondria; miRNAs; cerebral
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MDPI and ACS Style

Hu, Y.; Deng, H.; Xu, S.; Zhang, J. MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury. Int. J. Mol. Sci. 2015, 16, 24895-24917. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161024895

AMA Style

Hu Y, Deng H, Xu S, Zhang J. MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury. International Journal of Molecular Sciences. 2015; 16(10):24895-24917. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161024895

Chicago/Turabian Style

Hu, Yue, Hao Deng, Shixin Xu, and Junping Zhang. 2015. "MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury" International Journal of Molecular Sciences 16, no. 10: 24895-24917. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms161024895

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