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Mammalian Introns: When the Junk Generates Molecular Diversity

CNRS UMR7216, Epigenetics and Cell Fate, Université Paris Diderot, Sorbonne Paris Cité, UMR7216 Epigénétique et Destin Cellulaire, Bâtiment Lamarck B, Case Courrier 7042, 35 rue Hélène Brion, 75013 Paris, France
Authors to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Int. J. Mol. Sci. 2015, 16(3), 4429-4452;
Received: 16 December 2014 / Revised: 6 February 2015 / Accepted: 11 February 2015 / Published: 20 February 2015
(This article belongs to the Special Issue Pre-mRNA Splicing)
Introns represent almost half of the human genome, yet their vast majority is eliminated from eukaryotic transcripts through RNA splicing. Nevertheless, they feature key elements and functions that deserve further interest. At the level of DNA, introns are genomic segments that can shelter independent transcription units for coding and non-coding RNAs which transcription may interfere with that of the host gene, and regulatory elements that can influence gene expression and splicing itself. From the RNA perspective, some introns can be subjected to alternative splicing. Intron retention appear to provide some plasticity to the nature of the protein produced, its distribution in a given cell type and timing of its translation. Intron retention may also serve as a switch to produce coding or non-coding RNAs from the same transcription unit. Conversely, splicing of introns has been directly implicated in the production of small regulatory RNAs. Hence, splicing of introns also appears to provide plasticity to the type of RNA produced from a genetic locus (coding, non-coding, short or long). We addressed these aspects to add to our understanding of mechanisms that control the fate of introns and could be instrumental in regulating genomic output and hence cell fate. View Full-Text
Keywords: intron; splicing; genome; gene; non-coding RNA; transcription; data mining intron; splicing; genome; gene; non-coding RNA; transcription; data mining
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MDPI and ACS Style

Hubé, F.; Francastel, C. Mammalian Introns: When the Junk Generates Molecular Diversity. Int. J. Mol. Sci. 2015, 16, 4429-4452.

AMA Style

Hubé F, Francastel C. Mammalian Introns: When the Junk Generates Molecular Diversity. International Journal of Molecular Sciences. 2015; 16(3):4429-4452.

Chicago/Turabian Style

Hubé, Florent, and Claire Francastel. 2015. "Mammalian Introns: When the Junk Generates Molecular Diversity" International Journal of Molecular Sciences 16, no. 3: 4429-4452.

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