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Article

MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line

1
Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China
2
Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China
3
Department of Pharmacy, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing 100022, China
4
Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China
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Institute of Radiation, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2015, 16(9), 22137-22150; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms160922137
Received: 6 July 2015 / Revised: 27 August 2015 / Accepted: 27 August 2015 / Published: 14 September 2015
(This article belongs to the Special Issue MicroRNA Regulation)
MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy. View Full-Text
Keywords: non-small cell lung cancer; microrna122; adenoviral vector; ionizing radiation; radiosensitization non-small cell lung cancer; microrna122; adenoviral vector; ionizing radiation; radiosensitization
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MDPI and ACS Style

Ma, D.; Jia, H.; Qin, M.; Dai, W.; Wang, T.; Liang, E.; Dong, G.; Wang, Z.; Zhang, Z.; Feng, F. MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line. Int. J. Mol. Sci. 2015, 16, 22137-22150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms160922137

AMA Style

Ma D, Jia H, Qin M, Dai W, Wang T, Liang E, Dong G, Wang Z, Zhang Z, Feng F. MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line. International Journal of Molecular Sciences. 2015; 16(9):22137-22150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms160922137

Chicago/Turabian Style

Ma, Debin, Hui Jia, Mengmeng Qin, Wenjie Dai, Tao Wang, Erguang Liang, Guofu Dong, Zuojun Wang, Zhiyuan Zhang, and Fan Feng. 2015. "MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line" International Journal of Molecular Sciences 16, no. 9: 22137-22150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms160922137

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