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Review

The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

1
Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
2
Department of Pharmacology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Mol. Sci. 2016, 17(1), 137; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17010137
Received: 25 September 2015 / Revised: 14 January 2016 / Accepted: 15 January 2016 / Published: 21 January 2016
Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed to various stresses, such as chemotherapy. While the administration of gemcitabine, an anti-tumor drug, has been the standard treatment for patients with advanced pancreatic cancer, accumulating evidence shows that HSP27 plays a key role in the chemosensitivity to gemcitabine. In addition, phosphorylated HSP27 induced by gemcitabine has been associated with the inhibition of pancreatic cancer cell growth. In this review, we summarize the role of phosphorylated HSP27, as well as HSP27, in the regulation of chemosensitivity in pancreatic cancer. View Full-Text
Keywords: HSP27; pancreatic cancer; phosphorylated HSP27; chemosensitivity; prognosis HSP27; pancreatic cancer; phosphorylated HSP27; chemosensitivity; prognosis
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MDPI and ACS Style

Okuno, M.; Adachi, S.; Kozawa, O.; Shimizu, M.; Yasuda, I. The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer. Int. J. Mol. Sci. 2016, 17, 137. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17010137

AMA Style

Okuno M, Adachi S, Kozawa O, Shimizu M, Yasuda I. The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer. International Journal of Molecular Sciences. 2016; 17(1):137. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17010137

Chicago/Turabian Style

Okuno, Mitsuru, Seiji Adachi, Osamu Kozawa, Masahito Shimizu, and Ichiro Yasuda. 2016. "The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer" International Journal of Molecular Sciences 17, no. 1: 137. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17010137

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