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Review

Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome

Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Atsushi Matsuzawa
Int. J. Mol. Sci. 2016, 17(10), 1638; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101638
Received: 31 July 2016 / Revised: 16 September 2016 / Accepted: 20 September 2016 / Published: 27 September 2016
(This article belongs to the Special Issue Kinase Signal Transduction)
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. Maintenance of the DDR is essential to prevent development of diseases caused by genomic instability, including cancer, defects of development, and neurodegenerative disorders. Recent studies reveal a novel HIPK2-mediated pathway for DDR through interaction with chromatin remodeling factor homeodomain protein 1γ. In this review, we will highlight the molecular mechanisms of HIPK2 and show its functions as a crucial DDR regulator. View Full-Text
Keywords: DNA damage responses; HIPK2; HP1γ; cell cycle; apoptosis DNA damage responses; HIPK2; HP1γ; cell cycle; apoptosis
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MDPI and ACS Style

Kuwano, Y.; Nishida, K.; Akaike, Y.; Kurokawa, K.; Nishikawa, T.; Masuda, K.; Rokutan, K. Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. Int. J. Mol. Sci. 2016, 17, 1638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101638

AMA Style

Kuwano Y, Nishida K, Akaike Y, Kurokawa K, Nishikawa T, Masuda K, Rokutan K. Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. International Journal of Molecular Sciences. 2016; 17(10):1638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101638

Chicago/Turabian Style

Kuwano, Yuki, Kensei Nishida, Yoko Akaike, Ken Kurokawa, Tatsuya Nishikawa, Kiyoshi Masuda, and Kazuhito Rokutan. 2016. "Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome" International Journal of Molecular Sciences 17, no. 10: 1638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101638

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