Next Article in Journal
Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines
Next Article in Special Issue
Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease
Previous Article in Journal
Extracellular Self-DNA (esDNA), but Not Heterologous Plant or Insect DNA (etDNA), Induces Plasma Membrane Depolarization and Calcium Signaling in Lima Bean (Phaseolus lunatus) and Maize (Zea mays)
Previous Article in Special Issue
Protein Kinases and Parkinson’s Disease
Review

Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival

1
Department of Physiology, School of Medicine, Faculty of Medicine, Toho University, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan
2
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
3
Department of Molecular Physiology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Int. J. Mol. Sci. 2016, 17(10), 1652; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101652
Received: 31 August 2016 / Revised: 21 September 2016 / Accepted: 22 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Neuroprotective Strategies 2016)
Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches. View Full-Text
Keywords: chlorogenic acid; glutamate neurotoxicity; hydrogen sulfide; neuroprotection; nitric oxide chlorogenic acid; glutamate neurotoxicity; hydrogen sulfide; neuroprotection; nitric oxide
Show Figures

Figure 1

MDPI and ACS Style

Mikami, Y.; Kakizawa, S.; Yamazawa, T. Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival. Int. J. Mol. Sci. 2016, 17, 1652. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101652

AMA Style

Mikami Y, Kakizawa S, Yamazawa T. Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival. International Journal of Molecular Sciences. 2016; 17(10):1652. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101652

Chicago/Turabian Style

Mikami, Yoshinori, Sho Kakizawa, and Toshiko Yamazawa. 2016. "Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival" International Journal of Molecular Sciences 17, no. 10: 1652. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17101652

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop