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Article

Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein

1
Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan
2
Department of Hepatology, East Shonan General Hospital, Kanagawa 253-0083, Japan
3
Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan
4
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo 113-8431, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Tatsuo Kanda and William Chi-shing Cho
Int. J. Mol. Sci. 2016, 17(12), 2143; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122143
Received: 12 October 2016 / Revised: 30 November 2016 / Accepted: 14 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Hepatitis Virus Infection and Research)
We aimed to clarify the association between a novel serum fibrosis marker, Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP), and hepatocellular carcinoma (HCC) development in 355 patients with chronic hepatitis C who achieved sustained virologic response (SVR) through interferon-based antiviral therapy. Pretreatment serum WFA+-M2BP levels were quantified and the hazard ratios (HRs) for HCC development were retrospectively analyzed by Cox proportional hazard analysis. During the median follow-up time of 2.9 years, 12 patients developed HCC. Multivariate analysis demonstrated that high serum WFA+-M2BP (≥2.80 cut off index (COI), HR = 15.20, p = 0.013) and high fibrosis-4 (FIB-4) index (≥3.7, HR = 5.62, p = 0.034) were independent risk factors for HCC development. The three- and five-year cumulative incidence of HCC in patients with low WFA+-M2BP were 0.4% and 0.4%, respectively, whereas those of patients with high WFA+-M2BP were 7.7% and 17.6%, respectively (p < 0.001). In addition, combination of serum WFA+-M2BP and FIB-4 indices successfully stratified the risk of HCC: the five-year cumulative incidences of HCC were 26.9%, 6.8%, and 0.0% in patients with both, either, and none of these risk factors, respectively (p < 0.001). In conclusion, pretreatment serum WFA+-M2BP level is a useful predictor for HCC development after achieving SVR. View Full-Text
Keywords: WFA+-M2BP; hepatocellular carcinoma; chronic hepatitis C; risk factor; sustained virological response WFA+-M2BP; hepatocellular carcinoma; chronic hepatitis C; risk factor; sustained virological response
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MDPI and ACS Style

Sato, S.; Genda, T.; Ichida, T.; Amano, N.; Sato, S.; Murata, A.; Tsuzura, H.; Narita, Y.; Kanemitsu, Y.; Hirano, K.; Shimada, Y.; Iijima, K.; Wada, R.; Nagahara, A.; Watanabe, S. Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein. Int. J. Mol. Sci. 2016, 17, 2143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122143

AMA Style

Sato S, Genda T, Ichida T, Amano N, Sato S, Murata A, Tsuzura H, Narita Y, Kanemitsu Y, Hirano K, Shimada Y, Iijima K, Wada R, Nagahara A, Watanabe S. Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein. International Journal of Molecular Sciences. 2016; 17(12):2143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122143

Chicago/Turabian Style

Sato, Shunsuke, Takuya Genda, Takafumi Ichida, Nozomi Amano, Sho Sato, Ayato Murata, Hironori Tsuzura, Yutaka Narita, Yoshio Kanemitsu, Katsuharu Hirano, Yuji Shimada, Katsuyori Iijima, Ryo Wada, Akihito Nagahara, and Sumio Watanabe. 2016. "Prediction of Hepatocellular Carcinoma Development after Hepatitis C Virus Eradication Using Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein" International Journal of Molecular Sciences 17, no. 12: 2143. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17122143

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