Next Article in Journal
Pressure Combined with Ischemia/Reperfusion Injury Induces Deep Tissue Injury via Endoplasmic Reticulum Stress in a Rat Pressure Ulcer Model
Next Article in Special Issue
Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis
Previous Article in Journal
Physiological Investigation and Transcriptome Analysis of Polyethylene Glycol (PEG)-Induced Dehydration Stress in Cassava
Previous Article in Special Issue
K88 Fimbrial Adhesin Targeting of Microspheres Containing Gentamicin Made with Albumin Glycated with Lactose
Article

Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes

1
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece
2
School of Pharmacy, Department of Pharmaceutical Technology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey
3
School of Pharmacy, Department of Microbiology, Istanbul Medipol University, Beykoz, 34810 Istanbul, Turkey
4
Department of Physics, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece
5
Pharmathen S.A, Dervenakion Str. 6, 153 51 Attiki, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Már Másson
Int. J. Mol. Sci. 2016, 17(3), 282; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030282
Received: 24 January 2016 / Revised: 24 January 2016 / Accepted: 19 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(ε-caprolactone) (PCL) electrospun fibers and β-cyclodextrin (β-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for β-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and β-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation. View Full-Text
Keywords: PCL; fibers; inclusion complexation; voriconazole drug; antifungal PCL; fibers; inclusion complexation; voriconazole drug; antifungal
Show Figures

Graphical abstract

MDPI and ACS Style

Siafaka, P.I.; Üstündağ Okur, N.; Mone, M.; Giannakopoulou, S.; Er, S.; Pavlidou, E.; Karavas, E.; Bikiaris, D.N. Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. Int. J. Mol. Sci. 2016, 17, 282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030282

AMA Style

Siafaka PI, Üstündağ Okur N, Mone M, Giannakopoulou S, Er S, Pavlidou E, Karavas E, Bikiaris DN. Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes. International Journal of Molecular Sciences. 2016; 17(3):282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030282

Chicago/Turabian Style

Siafaka, Panoraia I., Neslihan Üstündağ Okur, Mariza Mone, Spyridoula Giannakopoulou, Sevda Er, Eleni Pavlidou, Evangelos Karavas, and Dimitrios N. Bikiaris 2016. "Two Different Approaches for Oral Administration of Voriconazole Loaded Formulations: Electrospun Fibers versus β-Cyclodextrin Complexes" International Journal of Molecular Sciences 17, no. 3: 282. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030282

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop