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Article

Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis

by 1,2, 1,2, 3, 3,4,*,† and 1,2,4,5,6,7,*,†
1
Department of Radiology, University of Missouri, Columbia, MO 65211, USA
2
Institute of Green Nanotechnology, University of Missouri, Columbia, MO 65211, USA
3
Department of Medicine, University of Missouri, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65211, USA
4
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
5
Department of Physics, University of Missouri, Columbia, MO 65211, USA
6
Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA
7
University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Már Másson
Int. J. Mol. Sci. 2016, 17(3), 316; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030316
Received: 6 November 2015 / Revised: 25 January 2016 / Accepted: 16 February 2016 / Published: 1 March 2016
(This article belongs to the Special Issue Drug Delivery and Antimicrobial Agents)
In our efforts to develop new approaches to treat and prevent human vascular diseases, we report herein our results on the proliferation and migration of human smooth muscles cells (SMCs) and endothelial cells (ECs) using epigallocatechin-3-gallate conjugated gold nanoparticles (EGCg-AuNPs) as possible alternatives to drug coated stents. Detailed in vitro stability studies of EGCg-AuNPs in various biological fluids, affinity and selectivity towards SMCs and ECs have been investigated. The EGCg-AuNPs showed selective inhibitory efficacy toward the migration of SMCs. However, the endothelial cells remained unaffected under similar experimental conditions. The cellular internalization studies have indicated that EGCg-AuNPs internalize into the SMCs and ECs within short periods of time through laminin receptor mediated endocytosis mode. Favorable toxicity profiles and selective affinity toward SMCs and ECs suggest that EGCg-AuNPs may provide attractive alternatives to drug coated stents and therefore offer new therapeutic approaches in treating cardiovascular diseases. View Full-Text
Keywords: epigallocatechin-3-gallate; gold nanoparticles; green synthesis; atherosclerosis epigallocatechin-3-gallate; gold nanoparticles; green synthesis; atherosclerosis
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MDPI and ACS Style

Khoobchandani, M.; Katti, K.; Maxwell, A.; Fay, W.P.; Katti, K.V. Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis. Int. J. Mol. Sci. 2016, 17, 316. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030316

AMA Style

Khoobchandani M, Katti K, Maxwell A, Fay WP, Katti KV. Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis. International Journal of Molecular Sciences. 2016; 17(3):316. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030316

Chicago/Turabian Style

Khoobchandani, Menka, Kavita Katti, Adam Maxwell, William P. Fay, and Kattesh V. Katti 2016. "Laminin Receptor-Avid Nanotherapeutic EGCg-AuNPs as a Potential Alternative Therapeutic Approach to Prevent Restenosis" International Journal of Molecular Sciences 17, no. 3: 316. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030316

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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