Next Article in Journal
Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders
Next Article in Special Issue
Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation
Previous Article in Journal
Myricetin Prevents Alveolar Bone Loss in an Experimental Ovariectomized Mouse Model of Periodontitis
Previous Article in Special Issue
The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery—A Pilot Study
Review

A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense

1
Center for Clinical and Translational Research, The Research Institute at Nationwide Children’s, Columbus, OH 43205, USA
2
Division of Pediatric Nephrology, Nationwide Children’s, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ester Boix
Int. J. Mol. Sci. 2016, 17(3), 423; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030423
Received: 13 February 2016 / Revised: 16 March 2016 / Accepted: 18 March 2016 / Published: 22 March 2016
(This article belongs to the Special Issue Antimicrobial RNases in Host Defense)
The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7’s antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases. View Full-Text
Keywords: ribonuclease; antimicrobial peptides; ribonuclease 7; innate immunity; infection; host defense ribonuclease; antimicrobial peptides; ribonuclease 7; innate immunity; infection; host defense
Show Figures

Graphical abstract

MDPI and ACS Style

Becknell, B.; Spencer, J.D. A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense. Int. J. Mol. Sci. 2016, 17, 423. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030423

AMA Style

Becknell B, Spencer JD. A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense. International Journal of Molecular Sciences. 2016; 17(3):423. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030423

Chicago/Turabian Style

Becknell, Brian, and John D. Spencer 2016. "A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense" International Journal of Molecular Sciences 17, no. 3: 423. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17030423

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop