Next Article in Journal
High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer
Previous Article in Journal
Metabolomic Studies of Oral Biofilm, Oral Cancer, and Beyond
Previous Article in Special Issue
Enrichment of Secondary Wastewater Sludge for Production of Hydrogen from Crude Glycerol and Comparative Evaluation of Mono-, Co- and Mixed-Culture Systems
Review

Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria

1
Natural Products and Industrial Biochemistry Research Group (NPIB), Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam
2
Microbial Processes and Interactions (MiPI), Agro-biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
3
Faculty of Applied Sciences, Ton Duc Thang University, 19 Nguyen Huu Tho, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam
4
Food technology and Formulation, Agro-Biochem Department, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
*
Authors to whom correspondence should be addressed.
Academic Editor: Marianne Su-Ling Brooks
Int. J. Mol. Sci. 2016, 17(6), 867; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17060867
Received: 26 March 2016 / Revised: 17 May 2016 / Accepted: 18 May 2016 / Published: 2 June 2016
(This article belongs to the Special Issue Bioprocess Engineering)
The literature presents a growing body of evidence demonstrating the positive effect of probiotics on health. Probiotic consumption levels are rising quickly in the world despite the fluctuation of their viability and functionality. Technological methods aiming at improving probiotic characteristics are thus highly wanted. However, microbial metabolic engineering toolbox is not available for this kind of application. On the other hand, basic microbiology teaches us that bacteria are able to exhibit adaptation to external stresses. It is known that adequately applied sub-lethal stress, i.e., controlled in amplitude and frequency at a given stage of the culture, is able to enhance microbial robustness. This property could be potentially used to improve the viability of probiotic bacteria, but some technical challenges still need to be overcome before any industrial implementation. This review paper investigates the different technical tools that can be used in order to define the proper condition for improving viability of probiotic bacteria and their implementation at the industrial scale. Based on the example of Bifidobacterium bifidum, potentialities for simultaneously improving viability, but also functionality of probiotics will be described. View Full-Text
Keywords: biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness biochemical engineering; prebiotics; probiotics; exopolysaccharide; sub-lethal stress; survival; cellular robustness
Show Figures

Graphical abstract

MDPI and ACS Style

Nguyen, H.-T.; Truong, D.-H.; Kouhoundé, S.; Ly, S.; Razafindralambo, H.; Delvigne, F. Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria. Int. J. Mol. Sci. 2016, 17, 867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17060867

AMA Style

Nguyen H-T, Truong D-H, Kouhoundé S, Ly S, Razafindralambo H, Delvigne F. Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria. International Journal of Molecular Sciences. 2016; 17(6):867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17060867

Chicago/Turabian Style

Nguyen, Huu-Thanh, Dieu-Hien Truong, Sonagnon Kouhoundé, Sokny Ly, Hary Razafindralambo, and Frank Delvigne. 2016. "Biochemical Engineering Approaches for Increasing Viability and Functionality of Probiotic Bacteria" International Journal of Molecular Sciences 17, no. 6: 867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17060867

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop