Next Article in Journal
Enhancing Signal Output and Avoiding BOD/Toxicity Combined Shock Interference by Operating a Microbial Fuel Cell Sensor with an Optimized Background Concentration of Organic Matter
Next Article in Special Issue
In Vitro Co-Culture Models of Breast Cancer Metastatic Progression towards Bone
Previous Article in Journal
Assessing the Effects of Acute Amyloid β Oligomer Exposure in the Rat
Previous Article in Special Issue
Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
Review

Bone Density as a Marker of Response to Radiotherapy in Bone Metastatic Lesions: A Review of the Published Data

1
2nd Department Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens, ATTIKON University Hospital, 12462 Athens, Greece
2
1st Department Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Alfonsina Desiderio
Int. J. Mol. Sci. 2016, 17(9), 1391; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17091391
Received: 15 July 2016 / Revised: 16 August 2016 / Accepted: 19 August 2016 / Published: 24 August 2016
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastasis)
Metastases to the bone are presenting in a great percentage of patients with cancer, causing a variety of symptoms, affecting the quality of life and survival of patients. A multidisciplinary approach from different health providers is required for treatment, including radiation oncologists, medical oncologists and surgeons. The role of radiotherapy in the management of bone metastases has long been established through multiple randomized trials. The estimation of response to the therapy is subjective and is based on the palliation of the symptoms that the patients report. However, a quantification of the tumor burden and response to the treatment with the use of an objective method to measure those parameters is a clinical expectation in oncology. The change in bone density in affected areas (mainly lytic) after local radiotherapy, representing the cellular changes that have occurred, is a promising marker of response to treatment. View Full-Text
Keywords: bone metastasis; radiotherapy; bone density bone metastasis; radiotherapy; bone density
Show Figures

Graphical abstract

MDPI and ACS Style

Kouloulias, V.; Liakouli, Z.; Zygogianni, A.; Mystakidou, K.; Kouvaris, J.R. Bone Density as a Marker of Response to Radiotherapy in Bone Metastatic Lesions: A Review of the Published Data. Int. J. Mol. Sci. 2016, 17, 1391. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17091391

AMA Style

Kouloulias V, Liakouli Z, Zygogianni A, Mystakidou K, Kouvaris JR. Bone Density as a Marker of Response to Radiotherapy in Bone Metastatic Lesions: A Review of the Published Data. International Journal of Molecular Sciences. 2016; 17(9):1391. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17091391

Chicago/Turabian Style

Kouloulias, Vassilis, Zoi Liakouli, Anna Zygogianni, Kyriaki Mystakidou, and John R. Kouvaris 2016. "Bone Density as a Marker of Response to Radiotherapy in Bone Metastatic Lesions: A Review of the Published Data" International Journal of Molecular Sciences 17, no. 9: 1391. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms17091391

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop