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Article

The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies

1
Department of Diagnostics, University Hospital, 31-501 Kraków, Poland
2
Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland
3
Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland
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2nd Department of Surgery, Jagiellonian University Medical College, 31-501 Kraków, Poland
5
Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland
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Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland
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Department of Pharmacology, Jagiellonian University Medical College, 31-531 Kraków, Poland
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Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland
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Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Srikumar Chellappan
Int. J. Mol. Sci. 2017, 18(1), 106; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010106
Received: 2 October 2016 / Revised: 26 December 2016 / Accepted: 29 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Pancreatic Disorders)
The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%–15% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in the early phase of the disease. We included 66 patients with AP, admitted within the first 24 h from the onset of symptoms. TBA were measured in serum at 24, 48, and 72 h from the onset of AP, using an automated fifth generation assay. The bilirubin-to-TBA ratio (B/TBA) was calculated. TBA was highest on the first day of AP and decreased subsequently. In patients with biliary etiology, serum TBA was significantly higher compared to those with alcoholic and other etiologies. B/TBA was significantly higher in patients with alcoholic etiology. At admission, the cut-off values of 4.7 µmol/L for TBA and 4.22 for the B/TBA ratio allowed for a differentiation between biliary and other etiologies of AP with a diagnostic accuracy of 85 and 83%. Both TBA and B/TBA may help in the diagnosis of AP etiology in the early phase of AP. View Full-Text
Keywords: idiopathic acute pancreatitis; total bile acids; biliary acute pancreatitis idiopathic acute pancreatitis; total bile acids; biliary acute pancreatitis
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MDPI and ACS Style

Maleszka, A.; Dumnicka, P.; Matuszyk, A.; Pędziwiatr, M.; Mazur-Laskowska, M.; Sporek, M.; Ceranowicz, P.; Olszanecki, R.; Kuźniewski, M.; Kuśnierz-Cabala, B. The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies. Int. J. Mol. Sci. 2017, 18, 106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010106

AMA Style

Maleszka A, Dumnicka P, Matuszyk A, Pędziwiatr M, Mazur-Laskowska M, Sporek M, Ceranowicz P, Olszanecki R, Kuźniewski M, Kuśnierz-Cabala B. The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies. International Journal of Molecular Sciences. 2017; 18(1):106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010106

Chicago/Turabian Style

Maleszka, Aleksandra, Paulina Dumnicka, Aleksandra Matuszyk, Michał Pędziwiatr, Małgorzata Mazur-Laskowska, Mateusz Sporek, Piotr Ceranowicz, Rafał Olszanecki, Marek Kuźniewski, and Beata Kuśnierz-Cabala. 2017. "The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies" International Journal of Molecular Sciences 18, no. 1: 106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010106

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