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Article

Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

1
Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania
2
S.C. SANIMED INTERNATIONAL IMPEX S.R.L., Sos. Bucuresti-Magurele, nr.70, Sector 5, 051434 Bucharest, Romania
3
S.C. Biotehnos S.A., Gorunului Str. 3-5, 075100 Otopeni, Ilfov, Romania
4
Ştefan S. Nicolau Institute of Virology, 285 Mihai Bravu Avenue, Sector 3, 030304 Bucharest, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Chris Jackson
Int. J. Mol. Sci. 2017, 18(1), 175; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010175
Received: 30 October 2016 / Revised: 5 January 2017 / Accepted: 10 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene) and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC) values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics. View Full-Text
Keywords: plant-derived compounds; antimicrobial; acne; eugenol; β-pinene; eucalyptol; limonene plant-derived compounds; antimicrobial; acne; eugenol; β-pinene; eucalyptol; limonene
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MDPI and ACS Style

Saviuc, C.; Ciubucă, B.; Dincă, G.; Bleotu, C.; Drumea, V.; Chifiriuc, M.-C.; Popa, M.; Pircalabioru, G.G.; Marutescu, L.; Lazăr, V. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. Int. J. Mol. Sci. 2017, 18, 175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010175

AMA Style

Saviuc C, Ciubucă B, Dincă G, Bleotu C, Drumea V, Chifiriuc M-C, Popa M, Pircalabioru GG, Marutescu L, Lazăr V. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. International Journal of Molecular Sciences. 2017; 18(1):175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010175

Chicago/Turabian Style

Saviuc, Crina, Bianca Ciubucă, Gabriela Dincă, Coralia Bleotu, Veronica Drumea, Mariana-Carmen Chifiriuc, Marcela Popa, Gratiela G. Pircalabioru, Luminita Marutescu, and Veronica Lazăr. 2017. "Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds" International Journal of Molecular Sciences 18, no. 1: 175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18010175

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