Next Article in Journal
Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis
Next Article in Special Issue
Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy
Previous Article in Journal
MicroRNA-34a: A Versatile Regulator of Myriads of Targets in Different Cancers
Previous Article in Special Issue
Circadian Rhythms of Retinomotor Movement in a Marine Megapredator, the Atlantic Tarpon, Megalops atlanticus
Review

The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature

by 1,2 and 1,*,†
1
Department of Cell and Developmental Biology, University College London, London WC1E 6DE, UK
2
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
*
Author to whom correspondence should be addressed.
Current Address: Institute for Neuro- and Behavioral Biology, Westfälische Wilhelms University, 48149 Münster, Germany.
Int. J. Mol. Sci. 2017, 18(10), 2028; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102028
Received: 28 August 2017 / Revised: 13 September 2017 / Accepted: 14 September 2017 / Published: 3 October 2017
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Circadian Rhythms)
trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance. In this review, we discuss the evidence for a role of TRPA1 in the control of rhythmic behaviours in Drosophila melanogaster. Activity levels during the afternoon and rhythmic temperature preference are both regulated by TRPA1. In contrast, TRPA1 is dispensable for temperature synchronisation of circadian clocks. We discuss the neuronal basis of TRPA1-mediated temperature effects on rhythmic behaviours, and conclude that they are mediated by partly overlapping but distinct neuronal circuits. We have previously shown that TRPA1 is required to maintain siesta sleep under warm temperature cycles. Here, we present new data investigating the neuronal circuit responsible for this regulation. First, we discuss the difficulties that remain in identifying the responsible neurons. Second, we discuss the role of clock neurons (s-LNv/DN1 network) in temperature-driven regulation of siesta sleep, and highlight the role of TRPA1 therein. Finally, we discuss the sexual dimorphic nature of siesta sleep and propose that the s-LNv/DN1 clock network could play a role in the integration of environmental information, mating status and other internal drives, to appropriately drive adaptive sleep/wake behaviour. View Full-Text
Keywords: TRP channels; Drosophila; circadian clock; sleep; siesta; neuronal circuits; temperature sensing; temperature preference; temperature synchronisation; temperature entrainment TRP channels; Drosophila; circadian clock; sleep; siesta; neuronal circuits; temperature sensing; temperature preference; temperature synchronisation; temperature entrainment
Show Figures

Figure 1

MDPI and ACS Style

Roessingh, S.; Stanewsky, R. The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature. Int. J. Mol. Sci. 2017, 18, 2028. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102028

AMA Style

Roessingh S, Stanewsky R. The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature. International Journal of Molecular Sciences. 2017; 18(10):2028. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102028

Chicago/Turabian Style

Roessingh, Sanne, and Ralf Stanewsky. 2017. "The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature" International Journal of Molecular Sciences 18, no. 10: 2028. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102028

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop