Next Article in Journal
MicroRNA-34a: A Versatile Regulator of Myriads of Targets in Different Cancers
Next Article in Special Issue
Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System
Previous Article in Journal
Chemokines from a Structural Perspective
Previous Article in Special Issue
The Potential for Gut Organoid Derived Interstitial Cells of Cajal in Replacement Therapy
Review

Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies

1
Department of Research, Advanced Diagnostic, and Technological Innovation, Regina Elena National Cancer Institute, via E. Chianesi 53, Rome 00144, Italy
2
Stem Cells and Regenerative Medicine Laboratory, Foundation Institute of Pediatric Research “Città della Speranza”, corso Stati Uniti 4, Padova 35127, Italy
3
Department of Women’s and Children’s Health, University of Padova, Via Giustiniani 3, Padova 35128, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(10), 2087; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102087
Received: 31 August 2017 / Revised: 18 September 2017 / Accepted: 28 September 2017 / Published: 2 October 2017
(This article belongs to the Special Issue Stem Cell Research)
Cell-based therapies have the potential to revolutionize current treatments for diseases with high prevalence and related economic and social burden. Unfortunately, clinical trials have made only modest improvements in restoring normal function to degenerating tissues. This limitation is due, at least in part, to the death of transplanted cells within a few hours after transplant due to a combination of mechanical, cellular, and host factors. In particular, mechanical stress during implantation, extracellular matrix loss upon delivery, nutrient and oxygen deprivation at the recipient site, and host inflammatory response are detrimental factors limiting long-term transplanted cell survival. The beneficial effect of cell therapy for regenerative medicine ultimately depends on the number of administered cells reaching the target tissue, their viability, and their promotion of tissue regeneration. Therefore, strategies aiming at improving viable cell engraftment are crucial for regenerative medicine. Here we review the major factors that hamper successful cell engraftment and the strategies that have been studied to enhance the beneficial effects of cell therapy. Moreover, we provide a perspective on whether mesenchymal stromal cell-derived extracellular vesicle delivery, as a cell-free regenerative approach, may circumvent current cell therapy limitations. View Full-Text
Keywords: anoikis; cell survival; cell therapy; cell transplantation; extracellular vesicles; hypoxia; mesenchymal stromal cells; regenerative medicine anoikis; cell survival; cell therapy; cell transplantation; extracellular vesicles; hypoxia; mesenchymal stromal cells; regenerative medicine
Show Figures

Graphical abstract

MDPI and ACS Style

Baldari, S.; Di Rocco, G.; Piccoli, M.; Pozzobon, M.; Muraca, M.; Toietta, G. Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies. Int. J. Mol. Sci. 2017, 18, 2087. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102087

AMA Style

Baldari S, Di Rocco G, Piccoli M, Pozzobon M, Muraca M, Toietta G. Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies. International Journal of Molecular Sciences. 2017; 18(10):2087. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102087

Chicago/Turabian Style

Baldari, Silvia, Giuliana Di Rocco, Martina Piccoli, Michela Pozzobon, Maurizio Muraca, and Gabriele Toietta. 2017. "Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies" International Journal of Molecular Sciences 18, no. 10: 2087. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102087

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop