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Review

Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation

1
Université de Bourgogne Franche-Comté, LNC UMR1231, 21000 Dijon, France
2
Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, 21000 Dijon, France
Int. J. Mol. Sci. 2017, 18(10), 2188; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102188
Received: 15 September 2017 / Revised: 11 October 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Ubiquitin System)
Ubiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast. It contributes to the rapid adaptation of the cells to physiological intracellular variations and to intracellular or environmental stresses. E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. Its expression and activity are tightly regulated over the course of the cell cycle progression and in response to genotoxic stress. I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1’s regulation. View Full-Text
Keywords: E2F1; ubiquitination; cell cycle; DNA damage E2F1; ubiquitination; cell cycle; DNA damage
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MDPI and ACS Style

Dubrez, L. Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation. Int. J. Mol. Sci. 2017, 18, 2188. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102188

AMA Style

Dubrez L. Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation. International Journal of Molecular Sciences. 2017; 18(10):2188. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102188

Chicago/Turabian Style

Dubrez, Laurence. 2017. "Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation" International Journal of Molecular Sciences 18, no. 10: 2188. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102188

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