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The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain

Department of Anatomy, Chonnam National University Medical School, Gwangju 61469, Korea
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Int. J. Mol. Sci. 2017, 18(11), 2493; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112493
Received: 30 October 2017 / Revised: 17 November 2017 / Accepted: 20 November 2017 / Published: 22 November 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Alzheimer’s disease (AD), characterized by the aggregation of amyloid-β (Aβ) protein and neuroinflammation, is the most common neurodegenerative disease globally. Previous studies have reported that some AD patients show impaired glucose utilization in brain, leading to cognitive decline. Recently, diabetes-induced dementia has been called “type 3 diabetes”, based on features in common with those of type 2 diabetes and the progression of AD. Impaired glucose uptake and insulin resistance in the brain are important issues in type 3 diabetes, because these problems ultimately aggravate memory dysfunction in the brain. Glucagon-like peptide 1 (GLP-1) has been known to act as a critical controller of the glucose metabolism. Several studies have demonstrated that GLP-1 alleviates learning and memory dysfunction by enhancing the regulation of glucose in the AD brain. However, the specific actions of GLP-1 in the AD brain are not fully understood. Here, we review evidences related to the role of GLP-1 in type 3 diabetes. View Full-Text
Keywords: glucagon like peptide 1 (GLP-1); type 3 diabetes; diabetes-induced dementia; Alzheimer’s disease (AD); insulin resistance; Amyloid beta (Aβ) glucagon like peptide 1 (GLP-1); type 3 diabetes; diabetes-induced dementia; Alzheimer’s disease (AD); insulin resistance; Amyloid beta (Aβ)
MDPI and ACS Style

Bae, C.S.; Song, J. The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain. Int. J. Mol. Sci. 2017, 18, 2493. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112493

AMA Style

Bae CS, Song J. The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain. International Journal of Molecular Sciences. 2017; 18(11):2493. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112493

Chicago/Turabian Style

Bae, Choon S., and Juhyun Song. 2017. "The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain" International Journal of Molecular Sciences 18, no. 11: 2493. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112493

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