Next Article in Journal
Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin
Next Article in Special Issue
Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature
Previous Article in Journal
Metabolic Epilepsies—Commemorative Issue in Honor of Professor Uwe Heinemann
Previous Article in Special Issue
Infectious Agents in Atherosclerotic Cardiovascular Diseases through Oxidative Stress
Review

A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD

by 1,2 and 2,3,*
1
Center for Neuroscience Research, Institute of Biomedical Science & Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
2
Department of Medical Science, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
3
Department of Rehabilitation Medicine, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2500; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112500
Received: 30 September 2017 / Revised: 20 November 2017 / Accepted: 21 November 2017 / Published: 22 November 2017
(This article belongs to the Special Issue Oxidative Stress in Vascular Diseases)
Oxidative stress (OS) is one of the factors that cause dementia conditions such as Alzheimer’s disease and vascular dementia (VaD). In the pathogenesis of VaD, OS is associated with risk factors that include increased age, hypertension, and stroke. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a molecular source of reactive oxygen species (ROS). According to recent studies, inhibition of NOX activity can reduce cognitive impairment in animal models of VaD. In this article, we review the evidence linking cognitive impairment with NOX-dependent OS, including the vascular NOX and non-vascular NOX systems, in VaD. View Full-Text
Keywords: oxidative stress (OS); vascular dementia (VaD); reactive oxygen species (ROS); NADPH oxidases (NOX); cognitive impairment; risk factors oxidative stress (OS); vascular dementia (VaD); reactive oxygen species (ROS); NADPH oxidases (NOX); cognitive impairment; risk factors
Show Figures

Graphical abstract

MDPI and ACS Style

Choi, D.-H.; Lee, J. A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD. Int. J. Mol. Sci. 2017, 18, 2500. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112500

AMA Style

Choi D-H, Lee J. A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD. International Journal of Molecular Sciences. 2017; 18(11):2500. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112500

Chicago/Turabian Style

Choi, Dong-Hee, and Jongmin Lee. 2017. "A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD" International Journal of Molecular Sciences 18, no. 11: 2500. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18112500

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop