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Article

A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging

1
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Korea
2
Research Institute of Biotechnology and Medical Converged Science, Dongguk University (Seoul),Goyang 10326, Korea
3
The Food and Culture Institute, Pulmuone Co., Ltd., Seoul 03722, Korea
4
Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
5
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(3), 682; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030682
Received: 24 January 2017 / Revised: 28 February 2017 / Accepted: 13 March 2017 / Published: 22 March 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs). The 1:2 ratio of SE and HE mixture (SHM) showed the optimal benefit in vivo. SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression. SHM also inhibited mitogen-activated protein kinase (MAPK) phosphorylation and the transactivation of AP-1 which plays an important role in regulating MMP expression. These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling. View Full-Text
Keywords: soybean; Haematococcus; ultraviolet B; photoaging soybean; Haematococcus; ultraviolet B; photoaging
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MDPI and ACS Style

Shin, J.; Kim, J.-E.; Pak, K.-J.; Kang, J.I.; Kim, T.-S.; Lee, S.-Y.; Yeo, I.-H.; Park, J.H.Y.; Kim, J.H.; Kang, N.J.; Lee, K.W. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging. Int. J. Mol. Sci. 2017, 18, 682. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030682

AMA Style

Shin J, Kim J-E, Pak K-J, Kang JI, Kim T-S, Lee S-Y, Yeo I-H, Park JHY, Kim JH, Kang NJ, Lee KW. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging. International Journal of Molecular Sciences. 2017; 18(3):682. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030682

Chicago/Turabian Style

Shin, Jieun, Jong-Eun Kim, Kum-Ju Pak, Jung Il Kang, Tae-Seok Kim, Sang-Yoon Lee, Ik-Hyun Yeo, Jung Han Yoon Park, Jong Hun Kim, Nam Joo Kang, and Ki Won Lee. 2017. "A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging" International Journal of Molecular Sciences 18, no. 3: 682. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18030682

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