Next Article in Journal
Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology
Next Article in Special Issue
Delineating the Common Biological Pathways Perturbed by ASD’s Genetic Etiology: Lessons from Network-Based Studies
Previous Article in Journal
In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01
Previous Article in Special Issue
Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder?
Article

Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD)

1
Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA
2
Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA
3
Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA
4
Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
5
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(4), 698; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040698
Received: 21 February 2017 / Revised: 20 March 2017 / Accepted: 22 March 2017 / Published: 25 March 2017
Force control deficits have been repeatedly documented in autism spectrum disorder (ASD). They are associated with worse social and daily living skill impairments in patients suggesting that developing a more mechanistic understanding of the central and peripheral processes that cause them may help guide the development of treatments that improve multiple outcomes in ASD. The neuromuscular mechanisms underlying force control deficits are not yet understood. Seventeen individuals with ASD and 14 matched healthy controls completed an isometric index finger abduction test at 60% of their maximum voluntary contraction (MVC) during recording of the first dorsal interosseous (FDI) muscle to determine the neuromuscular processes associated with sustained force variability. Central modulation of the motorneuron pool activation of the FDI muscle was evaluated at delta (0–4 Hz), alpha (4–10 Hz), beta (10–35 Hz) and gamma (35–60 Hz) frequency bands. ASD patients showed greater force variability than controls when attempting to maintain a constant force. Relative to controls, patients also showed increased central modulation of the motorneuron pool at beta and gamma bands. For controls, reduced force variability was associated with reduced delta frequency modulation of the motorneuron pool activity of the FDI muscle and increased modulation at beta and gamma bands. In contrast, delta, beta, and gamma frequency oscillations were not associated with force variability in ASD. These findings suggest that alterations of central mechanisms that control motorneuron pool firing may underlie the common and often impairing symptoms of ASD. View Full-Text
Keywords: autism spectrum disorder (ASD); index finger abduction; force variability; motorneuron pool; first dorsal interosseus (FDI) muscle; decomposition-based electromyography (dEMG) autism spectrum disorder (ASD); index finger abduction; force variability; motorneuron pool; first dorsal interosseus (FDI) muscle; decomposition-based electromyography (dEMG)
Show Figures

Figure 1

MDPI and ACS Style

Wang, Z.; Kwon, M.; Mohanty, S.; Schmitt, L.M.; White, S.P.; Christou, E.A.; Mosconi, M.W. Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD). Int. J. Mol. Sci. 2017, 18, 698. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040698

AMA Style

Wang Z, Kwon M, Mohanty S, Schmitt LM, White SP, Christou EA, Mosconi MW. Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD). International Journal of Molecular Sciences. 2017; 18(4):698. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040698

Chicago/Turabian Style

Wang, Zheng, Minhyuk Kwon, Suman Mohanty, Lauren M. Schmitt, Stormi P. White, Evangelos A. Christou, and Matthew W. Mosconi 2017. "Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD)" International Journal of Molecular Sciences 18, no. 4: 698. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040698

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop