Next Article in Journal
Biosynthesis of α-Glucosidase Inhibitors by a Newly Isolated Bacterium, Paenibacillus sp. TKU042 and Its Effect on Reducing Plasma Glucose in a Mouse Model
Next Article in Special Issue
Subcellular Localization of Arabidopsis Pathogenesis-Related 1 (PR1) Protein
Previous Article in Journal
Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD)
Previous Article in Special Issue
Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways
Conference Report

Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology

1
Institute of Biosciences and Bioresources—Research Division of Perugia, National Research Council (CNR), via della Madonna Alta 130, 06128 Perugia, Italy
2
Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy
3
Centre for Plant Science, School of Biology, University of Leeds, Leeds LS2 9JT, UK
4
School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
5
Institute for Microbiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany
6
Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 1TN, UK
7
Department of Experimental Plant Biology, Faculty of Science, Charles University, 12844, Prague 2, Czech Republic
8
Institute of Experimental Botany, v.v.i., the Czech Academy of Sciences, 16502, Prague 6, Czech Republic
9
Department of Biological and Environmental Sciences and Technologies (DISTEBA), University of Salento, S.P. 6, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(4), 703; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040703
Received: 15 February 2017 / Revised: 22 March 2017 / Accepted: 23 March 2017 / Published: 25 March 2017
(This article belongs to the Special Issue Unconventional Proteins and Membranes Traffic)
Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on “Unconventional Protein and Membrane Traffic” (UPMT) during 4–7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes. View Full-Text
Keywords: protein secretion; intercellular channels; exosomes; autophagy; trafficking mechanisms; leaderless proteins; unconventional secretion protein secretion; intercellular channels; exosomes; autophagy; trafficking mechanisms; leaderless proteins; unconventional secretion
Show Figures

Figure 1

MDPI and ACS Style

Pompa, A.; De Marchis, F.; Pallotta, M.T.; Benitez-Alfonso, Y.; Jones, A.; Schipper, K.; Moreau, K.; Žárský, V.; Di Sansebastiano, G.P.; Bellucci, M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int. J. Mol. Sci. 2017, 18, 703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040703

AMA Style

Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. International Journal of Molecular Sciences. 2017; 18(4):703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040703

Chicago/Turabian Style

Pompa, Andrea, Francesca De Marchis, Maria Teresa Pallotta, Yoselin Benitez-Alfonso, Alexandra Jones, Kerstin Schipper, Kevin Moreau, Viktor Žárský, Gian Pietro Di Sansebastiano, and Michele Bellucci. 2017. "Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology" International Journal of Molecular Sciences 18, no. 4: 703. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040703

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop