Next Article in Journal
Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms
Next Article in Special Issue
ρ0 Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids
Previous Article in Journal
Studying Lactoferrin N-Glycosylation
Previous Article in Special Issue
SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways
Review

Regulation of Ubiquitin Enzymes in the TGF-β Pathway

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Academic Editor: Nobuhiro Nakamura
Int. J. Mol. Sci. 2017, 18(4), 877; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040877
Received: 24 March 2017 / Revised: 15 April 2017 / Accepted: 18 April 2017 / Published: 20 April 2017
(This article belongs to the Special Issue Ubiquitin System)
The transforming growth factor-β (TGF-β) pathway has a tumor suppressor role in normal and premalignant cells but promotes oncogenesis in advanced cancer cells. Components of the pathway are tightly controlled by ubiquitin modifying enzymes and aberrations in these enzymes are frequently observed to dysregulate the pathway causing diseases such as bone disorders, cancer and metastasis. These enzymes and their counterparts are increasingly being tested as druggable targets, and thus a deeper understanding of the enzymes is required. This review summarizes the roles of specific ubiquitin modifying enzymes in the TGF-β pathway and how they are regulated. View Full-Text
Keywords: transforming growth factor-β (TGF-β); ubiquitin; deubiquitylating enzymes (DUBs); SMAD ubiquitination regulatory factor (SMURF); ubiquitin–proteasome system (UPS) transforming growth factor-β (TGF-β); ubiquitin; deubiquitylating enzymes (DUBs); SMAD ubiquitination regulatory factor (SMURF); ubiquitin–proteasome system (UPS)
Show Figures

Figure 1

MDPI and ACS Style

Iyengar, P.V. Regulation of Ubiquitin Enzymes in the TGF-β Pathway. Int. J. Mol. Sci. 2017, 18, 877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040877

AMA Style

Iyengar PV. Regulation of Ubiquitin Enzymes in the TGF-β Pathway. International Journal of Molecular Sciences. 2017; 18(4):877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040877

Chicago/Turabian Style

Iyengar, Prasanna V. 2017. "Regulation of Ubiquitin Enzymes in the TGF-β Pathway" International Journal of Molecular Sciences 18, no. 4: 877. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18040877

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop