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Exploiting Epigenetic Alterations in Prostate Cancer

Drug Discovery, Bayer AG, Müllerstr. 178, 13353 Berlin, Germany
Author to whom correspondence should be addressed.
Academic Editor: Nicoletta Sacchi
Int. J. Mol. Sci. 2017, 18(5), 1017;
Received: 21 April 2017 / Revised: 4 May 2017 / Accepted: 4 May 2017 / Published: 9 May 2017
(This article belongs to the Special Issue Cancer Epigenetics)
Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including DNA and histone modifications have been identified in clinical prostate tumor samples. They have been linked to aberrant activity of enzymes and reader proteins involved in these epigenetic processes, leading to the search for dedicated inhibitory compounds. In the wake of encouraging anti-tumor efficacy results in preclinical models, epigenetic modulators addressing different targets are now being tested in prostate cancer patients. In addition, the assessment of microRNAs as stratification biomarkers, and early clinical trials evaluating suppressor microRNAs as potential prostate cancer treatment are being discussed. View Full-Text
Keywords: androgen receptor; epigenetics; histone; prostate cancer; microRNA androgen receptor; epigenetics; histone; prostate cancer; microRNA
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MDPI and ACS Style

Baumgart, S.J.; Haendler, B. Exploiting Epigenetic Alterations in Prostate Cancer. Int. J. Mol. Sci. 2017, 18, 1017.

AMA Style

Baumgart SJ, Haendler B. Exploiting Epigenetic Alterations in Prostate Cancer. International Journal of Molecular Sciences. 2017; 18(5):1017.

Chicago/Turabian Style

Baumgart, Simon J., and Bernard Haendler. 2017. "Exploiting Epigenetic Alterations in Prostate Cancer" International Journal of Molecular Sciences 18, no. 5: 1017.

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