Next Article in Journal
The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery
Previous Article in Journal
N-Caffeoyltryptamine, a Potent Anti-Inflammatory Phenolic Amide, Suppressed MCP-1 Expression in LPS-stimulated THP-1 Cells and Rats Fed a High-Fat Diet
Previous Article in Special Issue
State of the Art on Functional Virgin Olive Oils Enriched with Bioactive Compounds and Their Properties
Article

Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells

1
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
2
Área de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche C.P. 24040, Mexico
3
Grupo de Investigación en Polifenoles (GIP-USAL), Faculty of Pharmacy, Campus Miguel de Unamuno, Salamanca University, Salamanca E-37007, Spain
4
Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, 60131 Ancona, Italy
5
Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Centre, University of Granada, Granada C.P. 18000, Spain
6
Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA), Santander 39011, Spain
7
Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, 60131 Ancona, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Int. J. Mol. Sci. 2017, 18(6), 1149; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18061149
Received: 21 December 2016 / Revised: 18 May 2017 / Accepted: 23 May 2017 / Published: 28 May 2017
Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction. View Full-Text
Keywords: strawberry; anthocyanins; hypocholesterolemic; intracellular reactive oxygen species  diminution; antioxidant strawberry; anthocyanins; hypocholesterolemic; intracellular reactive oxygen species  diminution; antioxidant
Show Figures

Graphical abstract

MDPI and ACS Style

Forbes-Hernández, T.Y.; Gasparrini, M.; Afrin, S.; Cianciosi, D.; González-Paramás, A.M.; Santos-Buelga, C.; Mezzetti, B.; Quiles, J.L.; Battino, M.; Giampieri, F.; Bompadre, S. Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. Int. J. Mol. Sci. 2017, 18, 1149. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18061149

AMA Style

Forbes-Hernández TY, Gasparrini M, Afrin S, Cianciosi D, González-Paramás AM, Santos-Buelga C, Mezzetti B, Quiles JL, Battino M, Giampieri F, Bompadre S. Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. International Journal of Molecular Sciences. 2017; 18(6):1149. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18061149

Chicago/Turabian Style

Forbes-Hernández, Tamara Y., Massimiliano Gasparrini, Sadia Afrin, Danila Cianciosi, Ana M. González-Paramás, Celestino Santos-Buelga, Bruno Mezzetti, José L. Quiles, Maurizio Battino, Francesca Giampieri, and Stefano Bompadre. 2017. "Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells" International Journal of Molecular Sciences 18, no. 6: 1149. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18061149

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop