Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice
Abstract
:1. Introduction
2. Results
2.1. Cannabinoid Receptor 1 (CB1R)
2.2. Fatty Acid Amide Hydrolase (FAAH)
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Operant Sensation Seeking (OSS)
4.3. Data Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
2-AG | 2-Arachidonoylglycerol |
AEA | N-arachidonoylethanolamine |
CB1KO | Cannabinoid type 1 receptor knock out |
CB1R | Type 1 cannabinoid receptor |
ECS | Endocannabinoid signaling |
FAAH | Fatty acid amide hydrolase |
FAAHKO | Fatty acid amide hydrolase knock out |
FR | Fixed ratio |
mGluR5 | Metabotropic glutamate type 5 |
OSS | Operant sensation seeking |
PR | Progressive ratio |
SNP | Single nucleotide polymorphism |
VTA | Ventral tegmental area |
WT | Wild type |
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Schedule | Duration of Schedule | Activity Criteria | Correct Behavioral Acquisition | Deviation Criteria and Stable Responding |
---|---|---|---|---|
FR-1 | At least 6 sessions, no more than 12 | At least 20 reinforcers earned | 2:1 active:inactive response ratio | Reinforcers do not deviate beyond 20% of a 3 day moving average |
FR-2 | At least 3 sessions, no more than 6 | At least 15 reinforcers earned | ||
FR-4 | At least 3 sessions, no more than 6 | At least 15 reinforcers earned |
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Helfand, A.I.; Olsen, C.M.; Hillard, C.J. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. Int. J. Mol. Sci. 2017, 18, 1635. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18081635
Helfand AI, Olsen CM, Hillard CJ. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. International Journal of Molecular Sciences. 2017; 18(8):1635. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18081635
Chicago/Turabian StyleHelfand, Alexander I., Christopher M. Olsen, and Cecilia J. Hillard. 2017. "Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice" International Journal of Molecular Sciences 18, no. 8: 1635. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18081635